]> ACGT Master Ontology Cristian Cocos Holger Stenzhorn Insitute for Formal Ontology and Medical Information Science (IFOMIS) Mathias Brochhausen Sarah Lerch Ideally, the range should be confined to chemical processes def = "On the other side. The contralateral breast is the breast on the other breast. A stroke affecting the right side of the brain may cause contralateral paralysis, affecting the left arm and leg. The opposite of contralateral is ipsilateral which refers to the same side." Not sure what the domain might be though... see http://en.wikipedia.org/wiki/Medical_grafting def = "On the same side. A study of "ipsilateral breast tumor recurrence following lumpectomy and radiation therapy" pertains to cancer returning in the same breast as has been treated. A lesion in the right side of the brain may affect vision ipsilaterally, in the right eye." Not sure what the domain migh be though... There's another RO relation called "locationOf," which is why I have renamed this to locusOf. synonyms: assessment, evaluation old name: makesUseOfMedicalProcedure The corect way to deal with "reveals" is to make it a 3 place relation: x reveals quality of y. Existence is a property, so we shouldn't feel compelled to add "process" to the range. a part is a subsystem in case it has some contribution to the function of the greater system (i.e. is not causally inert) the key difference b/w participatesIn and undergoes is that the continuant that undergoes a process is the largest continuant that undergoes that process old name: undergoesMedicalProcedure old name: usedInMedicalProcedure ABVD is named after the initials of the chemotherapy drugs used, which are: doxorubicin (pronounced docks-o-rou-bi-sin, originally called Adriamycin®) bleomycin (blee o my sin), vinblastine (vin blas teen) and dacarbazine (de car b zeen). AC is named after the initials of the drugs used and involves the chemotherapy drugs doxorubicin (pronounced docks-o-rou-bi-sin, originally known as Adriamycin®) and cyclophosphamide (sigh clo fos fa mide). recommended by the American Joint Commission on Cancer aka AlkalinePhosphatase Level Alanine transaminase (ALT) Count CountingAbsoluteNeutrophils Absolute neutrophil count (ANC) aka Androgen receptor; the androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor which is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone. Aspartate transaminase (AST) Count Rhabdoid Tumor in the brain Short for Atypical Teratoid/Rhabdoid Tumor Abbr.: ANC Synonym: Dactinomycine 1 = treatment given after the primary treatment to increase the chances of a cure. Adjuvant therapy may include chemotherapy, radiation therapy or hormone therapy =Doxorubicin 1 0 0 0 0 Anthracyclines are a class of chemotherapeutic agents based upon daunosamine and tetra-hydro-naphthacene-dione. true 0 definition: No toxicity definition: Asymptomatic, no treatment definition: symptomatic, no treatment definition: Requiring treatment definition: Hypotension, life-threatening 0 0 0 0 0 BEP is named after the initials of the chemotherapy drugs used, which are: bleomycin (pronounced blee-o-my-sin), etoposide (e-top-o-side) and cisplatin (sis-pla-tin), which contains platinum. 0 Syn.: Beta Receptor-Blocker 0 0 aka serum sample 1 0 0 used for breast cancer; Wikipedia: The Bloom-Richardson grade (BR grade) is a a histologic grade assigned by pathologists to breast cancers. It is the most common type of cancer grade system currently used. It is a semi-quantitative grading method based on three morphologic features of invasive breast cancers. The morphologic features that are used are: degree of tumor tubule formation (percentage of cancer composed of tubular structures) tumor mitotic activity (rate of cell division) nuclear pleomorphism of tumor cells (nuclear grade, change in cell size and uniformity) Each of these features is assigned a score ranging from 1 to 3. The scores are then added together for a final sum that will range between 3 to 9. This value is then used to grade the tumor as follows : 3-5 Grade 1 tumor (well-differentiated). 6-7 Grade 2 tumor (moderately-differentiated). 8-9 Grade 3 tumor (poorly-differentiated). 1 aka BSA: In physiology and medicine, the body surface area (BSA) is the measured or calculated surface of a human body. For many clinical purposes BSA is a better indicator of metabolic mass than body weight because it is less affected by abnormal adipose mass. Estimation of BSA is simpler than many measures of volume. ? C-VAMP is named after the initials of the chemotherapy drugs used in the treatment, which are cyclophosphamide (pronounced sigh-clo-fos-fa-mide), vincristine (vin-chris-teen), doxorubicin (docks-o-rou-bi-sin, originally called Adriamycin®) and methyl-prednisolone (me-thile pred-ni-so-lone), which is a steroid. CAF is named after the initials of the drugs involved. These are: cyclophosphamide (pronounced sigh-clo-fos-fa-mide), doxorubicin (docks-o-roo-bi-sin, originally called Adriamycin®) and fluorouracil (floo-ro-you-ro-sill, also known as 5FU). CAV is named after the initials of the chemotherapy drugs used, which are: cyclophosphamide (pronounced sigh-clo-fos-fa-mide), doxorubicin (docks-o-rou-bi-sin), which was originally called Adriamycin® and vincristine (vin-chris-teen). Def.: The magnitude of the activity level of T cells. Def.: A purging process selecting the componenets of a sample by using antigen CD34 as indicator. The result is a sample of only stem cells. R-CHOP is named after the chemotherapy drugs used in the treatment. It involves the monoclonal antibody rituximab (pronounced ri-tucks-i-mab), and the drugs: cyclophosphamide (sigh-clo-fos-fa-mide), doxorubicin (docks-o-rou-bi-sin, originally called Adriamycin®), vincristine (vin-chris-teen, originally known as Oncovin®) and prednisolone (pred-ni-so-lone), which is a steroid. CMF is named after the initials of the chemotherapy drugs involved, which are cyclophosphamide (pronounced sigh-clo-fos-fa-mide), methotrexate (me-tho-trex-ate) and fluorouracil (floo-ro-you-ro-sill, which is also known as 5FU). 0 Chemotherapy regime according to the "Cooperative Weichteilsarkom Studie" 0 ALL FMA classes under "FMA: MaterialAnatomicalEntity" are subsumed here. The treatment involves the two chemotherapy drugs: capecitabine (pronounced cap-sight-a-been) and docetaxel (doe-se-tax-el), which is commonly called Taxotere® (tax-oh-tare). The treatment involves two chemotherapy drugs: carboplatin (pronounced car-bo-pla-tin) and etoposide (e-top-o-side), which is also known as Etopophos® or Vepesid®. 0 0 patients with no limitation of activities; they suffer no symptoms from ordinary activities. patients with slight, mild limitation of activity; they are comfortable with rest or with mild exertion. patients with marked limitation of activity; they are comfortable only at rest. patients who should be at complete rest, confined to bed or chair; any physical activity brings on discomfort and symptoms occur at rest. 0 0 0 0 0 0 0 0 1 0 0 0 0 1 ChlVPP is named after the initials of the chemotherapy drugs used, which are chlorambucil (pronounced claw-ram-bu-cil), vinblastine (vin-blas-teen), procarbazine (pro-car-ba-zeen) and prednisolone (pred-ni-so-lone), which is a steroid. 0 1 1 This treatment involves two chemotherapy drugs: cisplatin (pronounced sis-pla-tin) and fluorouracil (floo-ro-you-ro-sill); which is also known as 5FU. Clinical classification (Pretreatment clinical classification), designated TNM (or cTNM). This is based on evidence acquired before treatment. Such evidence arises from physical examination, imaging, endoscopy, biopsy, surgical exploration and other relevant examinations. aka Physical Examination 1 0 0 0 Name or other identifier of a clinical study in which the patient might be enrolled. ??????? aka "coagulation disorder" 0 Def.: Cobalt-60 is a chemical substance (a metal) that is radioactive and used in radiotherapy. aka MucinousCarcinoma 1 Common Toxicity Criteria (CTC) is a standardised classification of side effects used in assessing drugs for cancer therapy. Most US drug trials base their observations on this system which has a range of grades from 0-5, 5 usually equating to death. Currently version 3.0 is in use, released in 2003. 0 0 0 aka requirement; states of affairs play roles of criteria; how does one build a state of affairs in BFO?; probably reducible to quality and hasMeasurement--after all a state is the fact that some parameter has some value.... Food for further thought; for now it stays like this. Ductal Carcinoma In Situ, aka intraductal carcinoma DHAP is named after the drugs that are used in the treatment. This includes dexamethasone (pronounced decks-a-meth-a-sone), which is a steroid, and the chemotherapy drugs cytarabine (sigh-tare-a-been), which is sometimes called Ara C, and cisplatin (sis-pla-tin), which contains platinum. R-DHAP also includes the monoclonal antibody drug rituximab (Mabthera®). 1 The 'de Gramont' regimen is named after the doctor who first used it and involves the drugs fluorouracil (pronounced floo-ro-you-ro-sill), also known as 5FU and folinic acid, which is also known as leucovorin (loo-co-vor-rin). This is a drug that makes 5FU more effective. The de Gramont regimen is one of several different ways of combining these two drugs and each has a different name. Some doctors in the UK use a version of the de Gramont regime known as modified de Gramont, because they feel it is easier to give and just as effective. 0 ? o ld name: DiagnosticProcedure aka as Tumor Grade 1 1 1 1 The treatment involves two chemotherapy drugs, docetaxel (pronounced doe-se-tax-el), which is commonly known as Taxotere® (tax-oh-tare), and cisplatin (sis-pla-tin). 0 0 1 0 The treatment involves two chemotherapy drugs, doxorubicin (pronounced docks-o-rou-bi-sin) and ifosfamide (i-fos-fa-mide). You may sometimes hear this treatment being called AI after the drugs that are used (doxorubicin was originally called Adriamycin®). Other names for this treatment are Dox-Ifos and I-Ad. E-CMF, which is also known as Epi-CMF, is named after the initials of the four chemotherapy drugs involved: epirubicin (pronounced epi-roo-biss-sin), cyclophosphamide (sigh-clo-fos-fa-mide), methotrexate (me-tho-trex-ate) and fluorouracil (floo-ro-you-ro-sill), which is also known as 5FU. EC is named after the initials of the chemotherapy drugs used in the treatment, epirubicin (pronounced epi-roo-biss-sin) and cyclophosphamide (sigh-clo-fos-fa-mide). ECF is named after the initials of the chemotherapy drugs used, which are epirubicin (pronounced epi-roo-biss‑sin), cisplatin (sis-pla-tin) and fluorouracil (floo-ro-you-ro-sill), which is also known as 5FU. German: EKG aka the WHO or the Zubrod score ECX is named after the initials of the chemotherapy drugs used, which are epirubicin (pronounced epi-roo-biss-sin), cisplatin (sis-pla-tin) and capecitabine (kap-sight-a-been), which is also known as Xeloda® (ze-load-a). EEX is named after the initials of the drugs used, which are epirubicin (pronounced epi-roo-biss-sin), oxaliplatin (ox-ally-plat-in), which is also known as Eloxatin® (e-locks-a-tin) and capecitabine (kap-sight-a-been), also known as Xeloda® (ze-load-a). ELF is named after the initials of the chemotherapy drugs used, which are etoposide (pronounced e-top-o-side), leucovorin (loo-co-vor-rin), which is also known as folinic acid, and fluorouracil (floo-ro-you-ro-cil), also known as 5FU. aka Enzyme-linked immunosorbent assay An estrogen receptor (ER) is a nuclear receptor for estrogens such as estradiol (the main endogenous human estrogen). Estrogen receptors are intracellular proteins like other steroid hormone receptors. Estrogen Replacement Therapy ESHAP is named after the chemotherapy drugs used in the treatment, which are etoposide (pronounced e-top-o-side), methylprednisolone (me-thile-pred-ni-so-lone), which is a steroid, cytarabine (sigh-tare-a-been), which is sometimes known as Ara C and cisplatin (sis-pla-tin), which contains platinum. R-ESHAP also includes the drug rituximab (Mabthera®). Rituximab is a monoclonal antibody which is is used to treat several different types of B-cell non-Hodgkin's lymphoma. Monoclonal antibodies are used to try to destroy some types of cancer cells, while causing little harm to normal cells. They are designed to recognise and attach themselves (like a key in a lock) to certain proteins that are found on the surface of some cancer cells. This may then trigger the body’s immune system to attack the cancer cells and can sometimes cause the cells to destroy themselves. Rituximab locks onto a protein called CD20, which is found on the surface of one of the main types of normal white blood cells (B-cell lymphocytes). It is also present on the surface of most of the abnormal B-cell lymphocytes that occur in some types of non-Hodgkin's lymphoma. Rituximab acts by attacking both abnormal (malignant) and normal B-cell lymphocytes. However, the body can quite quickly replace any normal white blood cells that are damaged. End-systolic volume (ESV) is the volume of blood in the left ventricle at the end of contraction, or systole, and the beginning of filling, or diastole. End systolic volume can be used clinically as a measurement of the adequacy of cardiac emptying, related to systolic function. Identification Number according to the European Rhabdoid Study aka inclusion criterion Def.: The Organismal Process of acceptence of new donor stem cells or bone marrow by an organism. The process is indicated by the production of new blood cells The chemotherapy drugs used in this treatment are etoposide (pronounced e-top-o-side) and cisplatin (sis-pla-tin). aka Tumorectomy; an "excisional biopsy" (sometimes called a "tumorectomy") is the removal of a tumor with a minimum of healthy tissue. It is therefore an excision rather than a biopsy. 0 FEC is named after the initials of the chemotherapy drugs used, which are fluorouracil (pronounced floo-ro-you-ro-sill), which is also known as 5FU, epirubicin (epi-roo-biss-sin) and cyclophosphamide (sigh-clo-fos-fa-mide). 0 0 0 0 0 aka Aspiration or FNA biopsy 0 0 0 0 used for kidney cancer NG: Further treatment in another clinic means, if a hospital makes the diagnosis of cancer and only starts to treat and then referes the patient to another hospital, then further treatment is given in another clinic. Further treatment can be protocol treatment and non-protocol treatment. E.g. it can be protocol treatment in another hospital but protocol treatment. But it can also be other treatment. It has to be specified in the CRFs comments. Well-differentiated (Low grade) Moderately differentiated (Intermediate grade) Poorly differentiated (High grade) Undifferentiated (High grade); undifferentiated = a term used to describe cells or tissues that do not have specialized ("mature") structures or functions. Undifferentiated cancer cells often grow and spread quickly. Grade cannot be assessed (Undetermined grade) GemCap is named after the drugs used and involves the chemotherapy drugs: gemcitabine (pronounced jem-sight-a-been), which is also known as Gemzar® and capecitabine (cap-sight-a-been), also known as Xeloda® (ze-load-a). GemCarbo is named after the chemotherapy drugs used in the treatment, which are gemcitabine (pronounced gem-sight-a-been), which is also known as Gemzar® and carboplatin (car-bo-pla-tin). GemTaxol is named after the chemotherapy drugs used, which are gemcitabine (pronounced gem-sight-a-been), which is also known as Gemzar®, and paclitaxel (pak-li-tax-el), which is commonly called Taxol (tax-ol). The treatment involves the two chemotherapy drugs gemcitabine (pronounced gem-sight-a-been), which is also known as Gemzar®, and cisplatin (sis-pla-tin). FMA? genomic type of a tumor used for prostate cancers; Gleason score = a system of grading prostate cancer tissue based on how it looks under a microscope. Gleason scores range from 2 to 10 and indicate how likely it is that a tumor will spread. A low Gleason score means the cancer tissue is similar to normal prostate tissue and the tumor is less likely to spread; a high Gleason score means the cancer tissue is very different from normal and the tumor is more likely to spread. 0 GnRH = gonadotropin releasing hormone aka GCSF; Granulocyte Colony-Stimulating Factor (G-CSF or GCSF) is a hormone. It is a glycoprotein, growth factor or cytokine produced by a number of different tissues to stimulate the bone marrow to produce granulocytes and stem cells. G-CSF then stimulates the bone marrow to pulse them out of the marrow into the blood. It also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils. 0 Chemotherapy Regime according to the "Hirntumorstudien" Hormone Replacement Therapy (HRT) is medication containing one or more female hormones, commonly estrogen plus progestin (synthetic progesterone). hemoglobin? 0 0 0 definition: Normal function, shortening fraction >30% definition: Asymptomatic decline resting ejection fraction of >10% but <20% of baseline value, shortening fraction >25% but <30% definition: Asymptomatic decline resting ejection fraction of >20% but <25% of baseline value, shortening fraction >20% but <25% definiton: Congestive heart failure responsive to treatment, shortening fraction >15% but <20% definition: Severe or refractory congestive heart failure or requiring intubation, shortening fraction <15% 0 The processes that implement the canonical functioning of the heart. 1 aka WBC 0 0 0 sample of tissue sectioned as a thin slice should have child HistopathologicalType? 1 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0 1 0 1 0 0 0 0 0 0 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 aka Immunocytochemistry; Immunocytochemistry differs from immunohistochemistry (IHC) in that the former is performed on samples of intact cells that have had most, if not all, their surrounding extracellular matrix removed. Def. A chemotherapy based on Ifosfamide, Carboplatin and Etoposide. aka Immunohistochemical staining 1 1 0 aka Immuno-electron microscopy 0 0 no infection mild infection medium infection; agent not identified heavy infection; agent identified 1 0 0 Best would be to replace "Institution hasIdentifier some InstitutionIdentifier" with "Institution hasIdentifier min 0 InstitutionIdentifier," however that is a QCR, and would probably generate OWL issues. As such, the constraint may be factually inaccurate, though certainly accurate and useful in ACGT context. 0 Intracellular receptors are receptors located inside the cell rather than on its cell membrane. 0 aka "no special type" This treatment involves the following chemotherapy drugs irinotecan (pronounced eye-ri-no-tee-can), fluorouracil (floo-ro-you-ro-sill), which is also known as 5FU, and a drug called folinic (fol-in-ic) acid, which is also known as leucovorin (loo-co-vor-rin). Folinic acid makes 5FU more effective. 5FU and folinic acid are commonly given together to treat bowel cancer. The combination of these two drugs can be given in different ways, and is often known as the 'de Gramont' regime, or modified de Gramont. When irinotecan is given with de Gramont it is sometimes called FOLFIRI. When irinotecan is given with modified de Gramont, it may be called IrMdG. Def.: An isodose is a two-dimensional region (a surface or a line) that covers all point of the same energy dose or ionic dose. 1 Number a pathologist assigns to a case. If more than on histologies of a single patient are examined, each histological specimen gets its own JournalNumber. http://en.wikipedia.org/wiki/Performance_status dead moribund, rapidly progressive fatal disease processes normal, no complaints, no signs of disease very ill, urgently requiring admission, requires supportive measures or treatment severely disabled, hospital admission indicated but no risk of death disabled, requires special care and help requires help often, requires frequent medical care requiring some help, can take care of most personal requirements caring for self, not capable of normal activity or work normal activity with some difficulty, some symptoms or signs capable of normal activity, few symptoms or signs of disease 0 0 The processes that implement the canonical functioning of the kidney. LH-RH means Luteinizing Hormone-Releasing Hormone. It is a Releasing hormone, i.e. a hormone whose main purpose is to control the release of another hormone, here the Luteinizing hormone. 1 Left Ventricular Ejection Fraction 1 Shortening Fraction Of The Left Ventricle http://en.wikipedia.org/wiki/Performance_status unresponsive doesn't play; does not get out of bed fully active, normal sleeping often; play entirely limited to very passive activities bedbound; needing assistance even for quiet play mainly in bed; participates in quiet activities lying around much of the day, but gets dressed; no active playing participates in all quiet play and activities up and around, but active play minimal; keeps busy by being involved in quieter activities greater restriction of play and less time spent in play activity active, but tired more quickly minor restrictions in strenuous physical activity ? 0 0 Längsschnitt? 0 0 definition: No distant metastasis definition: Distant metastasis (includes metastasis to ipsilateral supraventricular lymph node[s]) definition: Distant metastasis classification MIC is named after the initials of the chemotherapy drugs used, which are mitomycin (pronounced my-toe-my-sin), ifosfamide (i-foss-fa-mide) and cisplatin (sis-pla-tin). MM is named after the initials of the chemotherapy drugs used, which are methotrexate (pronounced me-tho-trex-ate) and mitoxantrone (my-toe-zan-trone). Sometimes the term MM may be used to describe a combination of mitomycin and mitoxantrone. Our cancer support service nurses can give you further information about this regimen. MMM is named after the initials of the chemotherapy drugs used, which are mitomycin (pronounced my-toe-my-sin), methotrexate (me-tho-trex-ate) and mitozantrone (my-toe-zan-trone). Rhabdoid tumor in soft tissue (except kidney) MRT is short for Malign Rhabdoid Tumor MVP is named after the chemotherapy drugs used in the treatment, which are mitomycin (pronounced my-toe-my-sin), vinblastine (vin-blas-teen) and cisplatin (sis-pla-tin). definition: Presence of distant metastasis cannot be assessed 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 aka indicator 0 0 0 0 0 0 0 0 The Mayo regime (named after the hospital that started it) involves the drugs fluorouracil (pronounced floo-ro-you-ro-sill), which is a chemotherapy drug sometimes known as 5FU, and folinic (fol-in-ic) acid, which is a drug that makes 5FU more effective. It is also known as leucovorin (loo-co-vor-rin) or LV. 5FU and folinic acid are commonly used in the treatment of bowel cancer. It is important to know that the two drugs are often used together in different ways. This information is specifically about the Mayo regimen. doctor´s name 0 0 1 0 0 1 0 <